ESC

Publications

A curated record of peer-reviewed articles, preprints, reviews, and protocols from the Wang Lab.

§ 2026

Article

Cardiac fibroblast deletion of PTBP1 modulates the profibrotic response by alternative splicing.

Ricketts, S. N., Farber, G. M., Verma, S. K., Dong, Y., Xie, Y., Takasugi, P. R., Chen, S., Du, L., Wang, H., ... & Qian, L. · Nature Communications

Article

Spatially guided in vivo single-cell functional genomics of postnatal heart.

Wang, H.*, Dong, Y.*, Song, Y.*, Colon, M., Grosso, C., Yapundich, N., Ricketts, S., Liu, X., Farber, G., Liu, S. L., Qian, Y., Qian, L. and Liu, J. · Nature Cardiovascular Research · *co-first author

Article

IVNS1ABP mutation drives cellular senescence in newly identified progeroid neuropathy.

Yuan, F., Tan, Y. S., Wang, H., Ali, A. N., Yuan, Q., Chou, S. M., Yen, Y. H., Narayanan, G., Zhou, L., Shboul, M. and Bonnard, C. · Nature Communications

Article

Gfpt2 modulates fibroblast activation by glutathione metabolism.

Takasugi, P., Farber, G., Du, L., Ricketts, S. N., Rooney, S. E., Spurlock, B., Wang, H., Liu, J. and Qian, L. · Journal of Molecular and Cellular Cardiology

Preview

Rebuilding the bridge: Functional AVN cells for cardiac repair.

Wang, H. and Qian, L. · Cell Stem Cell

§ 2025

Preprint

GPTAnno: Ontology-tree-guided hierarchical cell type annotation based on GPT models for single-cell data.

Song, Y., Tang, M., Liu, Q., Wang, H., Qian, L., Zou, F. and Hou, W. · bioRxiv

Article

Sox17 and Erg synergistically activate endothelial cell fate in reprogramming fibroblasts.

Farber, G., Takasugi, P., Ricketts, S., Wang, H., Xie, Y., Farber, E., Liu, J. and Qian, L. · Journal of Molecular and Cellular Cardiology

§ 2024

Article

Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1.

Garbutt, T. A.*, Wang, Z.*, Wang, H.*, Ma, H., Ruan, H., Dong, Y., ... & Liu, J. · Circulation · *co-first author

Article

Decoding aging in the heart via single cell dual omics of non-cardiomyocytes.

Song, Y., Wang, L., Wang, H., Ma, H., Xu, J., Liu, J. and Qian, L. · iScience

Article

Single-cell chromatin accessibility profiling identifies intrinsic genetic program that activates transient pro-regenerative cell states of major non-myocyte cell types.

Dong, Y., Yang, Y., Wang, H., ... Liu, J. · Science Advances

Article

Direct highly efficient endothelial reprogramming using Sox17-Erg.

Farber, G., Wang, Q., Rathod, M., Wang, H., ... Qian, L. · Nature Communications

§ 2023

Article

Translational landscape of direct cardiac reprogramming reveals a role of Ybx1 in repressing cardiac fate acquisition.

Xie, Y., Wang, Q., Yang, Y., Near, D., Wang, H., Colon, M., ... & Qian, L. · Nature Cardiovascular Research

Article

Single-cell transcriptomics reveals maturation of transplanted stem cell-derived retinal pigment epithelial cells toward native state.

Parikh, B. H., Blakeley, P., Regha, K., Liu, Z., Yang, B., Bhargava, M., ... Wang, H., ... & Su, X. · Proceedings of the National Academy of Sciences

Protocol

Optimized protocol for direct cardiac reprogramming in mice using Ascl1 and Mef2c.

Wang, H.*, Keepers, B., Liu, J. and Qian, L. · STAR Protocols

§ 2022

Article

Cross-lineage Potential of Ascl1 Uncovered by Comparing Diverse Reprogramming Regulatomes.

Wang, H.*, Keepers, B.*, Qian, Y. Z., Colon, M., Liu, J. and Qian, L. · Cell Stem Cell

Article

Delineating chromatin accessibility re-patterning at single cell level during early stage of direct cardiac reprogramming.

Wang, H., Yang, Y., Qian, Y., Liu, J. and Qian, L. · Journal of Molecular and Cellular Cardiology

§ 2021

Review

Direct Cell Reprogramming: approaches and mechanisms.

Wang, H. F.*, Yang, Y. C.*, Liu, J. D. and Qian, L. · Nature Reviews Molecular Cell Biology

§ 2020

Article

Defining Essential Enhancers for Pluripotent Stem Cells Using a Features-Oriented CRISPR-Cas9 Screen.

Wang, H. F.*, Warrier, T.*, Farran, C. A., Zheng, Z. H., Xing, Q. R., Fullwood, M. J., Zhang, L. F., Li, H., Xu, J., Lim, T. M. and Loh, Y. H. · Cell Reports